Deok-Won Lee
Kyung-Hee University, South Korea
Title: Modifying titanium surfaces with nano-sized hydroxyapatite and simvastatin can enhance bone formation and osseointegration
Biography
Biography: Deok-Won Lee
Abstract
Introduction: The aim of the present study was to evaluate whether coating pristine titanium (Ti) with nano-sized hydroxyapatite (HAp) and simvastatin could enhance bone formation and osseointegration in vitro and in vivo because both HAp and simvastatin have the characteristic of osteogenetic induction.
Method and materials: Pristine Ti was sequentially surface-treated with NaOH,1,1-carbonyldiimidazole (CDI), beta-cyclodextrin-immobilized HAp powders (_-CD/HAp), and simvastatin before analysis using scanning electron microscopy (SEM), X-ray photoelectron microscopy (XPS), and static contact angle measurement.
Results: Simvastatin was released continually for up 28 days. Modification of the Ti surface with nano-sized HAp and simvastatin (Ti/_-CD/HAp/Sim) discs enhanced the osteogenic differentiation of MC3T3-E1 cells in vitro. Furthermore, Ti/_-CD/HAp/Sim of screw type enhanced bone formation between the screw and the host bone when the screw implanted to the proximal tibia and femoral head of rabbits.
Conclusion: These results suggest that surface modification of nano-sized HAp and simvastatin are effective tools for developing attractive dental implants.
This study was supported by a grant from the National Research Foundation of Korea (NRF-2014R1A1A1002630 and NRF-2016R1A2B4014600)
